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Wednesday, July 22, 2020 | History

2 edition of Effects of Myc on Haemopoietic Progenitor Cells found in the catalog.

Effects of Myc on Haemopoietic Progenitor Cells

A. I. Benjama

Effects of Myc on Haemopoietic Progenitor Cells

by A. I. Benjama

  • 40 Want to read
  • 33 Currently reading

Published by UMIST in Manchester .
Written in English


Edition Notes

StatementA. I. Benjama ; supervised by J. Owen-Lynch.
ContributionsOwen-Lynch, J., Biomolecular Sciences.
ID Numbers
Open LibraryOL17420206M

Hematopoietic Progenitor Cells, Cord Blood (Intravenous Route) Print. Sections. Description and Brand Names; Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. The hematopoietic progenitor cells go to the bone marrow where they become red blood cells, white blood cells, or platelets. These cells enter the blood stream and help restore low blood counts in patients with blood disorders. Hematopoietic progenitor cells, cord blood is to be given only by or under the immediate supervision of your doctor.

Assays have been developed to characterize hematopoietic stem and progenitor cells in vitro and in vivo. 16,17 In vivo assays that are used to study HSCs include Till and McCulloch's classical spleen colony forming (CFU-S) assay, 8 which measures the ability of HSC (as well as blood-forming progenitor cells) to form large colonies in the. Table Proposed cell-surface markers of undifferentiated hematopoietic stem cells. Listed here are cell surface markers found on mouse and human hematopoietic stem cells as they exist in their undifferentiated state in vivo and in vitro. As these cells begin to develop as distinct cell lineages the cell surface markers are no longer identified.

transfusion practice, haemostasis, adverse effects of blood transfusion and haemopoietic progenitor cells. Perhaps surprisingly, there is no chapter on immunohaematology. It is concise and accurate with sufficient background information for its target audience – the general clinician. This is not really a book for haematologists except. The CD34+ progenitor cells contain two main cellular subpopulations, hematopoietic and endothelial progenitor cells. Therefore, CD34+ progenitor cells are suitable for a series of studies including directed differentiation into more committed types of blood cells and endothelial lineages. Figure 2.


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Effects of Myc on Haemopoietic Progenitor Cells by A. I. Benjama Download PDF EPUB FB2

Haemopoietic Progenitor Cell (HPC) Sources & Collection. 20 June • Haematopoietic Progenitor Cell Collection via Apheresis or HPC, effect of tumour cell reinfusion is unknown.

Tumour cell mobilisation in leukaemia patients: may mobilise leukaemic cells and. Haemopoietic progenitor cells Specification for the uniform labelling of blood, blood components and blood donor samples Specification for. We describe here a novel approach to expand a cytokine-dependent Hematopoietic Stem and Progenitor Cell (HSPC) population ex vivo by culturing primary adult human or murine HSPCs with fusion proteins including the protein transduction domain of the HIV-1 transactivation protein (Tat) and either MYC or BclCited by: Conditional knockout of N-mycin neural stem and progenitor cells (NSC) leads to a profound disruption of brain growth attributable in part to altered NSC cell cycling (Knoepfler et al., ).

Although widely expressed in the murine embryo, L-mycappears to be dispensable for embryonic development (Hatton et Cited by:   It is unclear why this phenotype should be less severe than the embryonic Effects of Myc on Haemopoietic Progenitor Cells book (ocurring at day 18) re ported previously [27].

Possible effects of the insertion cassette on neigh bouring genes, or residual Pu.1 activity cannot be ruled out. The lineage commitment of haemopoietic progenitor cells Cross and Env: r Cited by: progenitor cells in various tissues and purified cell preparations, identify cytokines and other compounds that promote or inhibit hematopoiesis, and to determine the effects of manipulations such as cell processing, cryopreservation, ex vivo expansion and genetic modification on the viability and functional properties.

CD34 expression decreases with differentiation and the majority of late-stage progenitors (e.g., CFU-E) and end cells are CD 55, 56 Although enumeration of CD34 + cells by flow cytometry is a common method to measure the hematopoietic stem and progenitor cell content of grafts used for clinical transplantation, it is important to remember.

Haemopoietic progenitor cell processing standards Personnel and facilities. Processing facilities must comply with the requirements of the EU Directives on Tissues and Cells, FACT-JACIE Standards and NetCord-FACT Standards. There shall be a medical director/advisor who will have responsibility and authority for all clinical aspects of the programme including compliance with.

In fact, HSC research as a quantitative science emerged as a by-product of other investigative strategies seeking to determine how the consequences of myeloablation might be overcome. The seminal discovery was the finding of transplantable multipotent adult bone marrow cells with clonally demonstrable hematopoietic activity—a finding that evolved from experiments showing that an intravenous.

Hematopoietic progenitor cells (HPCs) or hematopoietic stem cells (HSCs) are cells present in blood and bone marrow. HPCs are capable of forming mature blood cells, such as red blood cells (the cells that carry oxygen), platelets (the cells that help stop bleeding) and white blood cells (the cells.

Hematopoietic stem cells are found in the bone marrow of adults, especially in the pelvis, femur, and sternum. They are also found in umbilical cord blood and, in small numbers, in peripheral blood. Stem and progenitor cells can be taken from the pelvis, at the iliac crest, using a needle and syringe.

TLR2/6 agonist treatment is associated with activation of Myc and mTORC1 in HPSCs. Toll-like receptor 2 (TLR2) expression is increased on hematopoietic stem and progenitor cells (HSPCs) of patients with myelodysplastic syndromes (MDS), and enhanced TLR2 signaling is thought to contribute to.

Cell culture. DF-1 cells, an immortalized line of chicken cells (Himly et al., ; Schaefer-Klein et al., ), were a generous gift of Douglas Foster (University of Minnesota).Plasmid forms of RCAS vectors were transfected into DF-1 cells using CaPO 4 and allowed to replicate as viral vectors in culture.

The supernatants from DF-1 cells infected with and producing either RCAS-MYC or RCAS. Platelet numbers and circulating haemopoietic progenitor cells were examined in 12 patients with advanced malignancies who were receiving recombinant. In contrast, little or no recovery was obtained for the adherent cell layer clonogenic capacity, even after hemin treatment.

These results clearly indicate a strong, long-lasting toxic effect on the bone marrow stroma and a limited recovery of hematopoietic potential by clonogenic cells of the nonadherent population after in vivo hemin treatment.

By analogy with the translocated c-myc oncogene in other B-lymphoid tumours (reviewed in ref. 7), bcl-2 is a candidate oncogene, but no biological effects of bcl-2 have yet been reported.

Leukaemic stem cells (LSCs) are responsible for BCR–ABL-driven chronic myeloid leukaemia relapse; here, p53 and MYC signalling networks are shown to regulate LSCs concurrently, and targeting. These data show that while Igh3′ RR is dispensable for lymphomas from progenitor B cells that have only undergone V(D)J recombination, it is required to activate c-myc in peripheral B cells.

Apoptosis of haemopoietic and epithelial progenitor cells may be mediated by p53 and c-myc (Hockenbery et al., ; Ryan et al., ), and Bcl-2 acts as an inhibitor of apoptosis (Chao & Korsmeyer, ). We determined whether any potential effect of theophylline on apoptosis could be linked to modulation of Bcl-2 expression.

Published: 24 November Stem cell biology. In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells. In vitro assays for studying haemopoietic progenitor cells are well developed.

We examined the effect of two benzene metabolites and lead nitrate on the in vitro growth potential of human haemopoietic progenitor cells derived from human cord blood.

The effects of lead nitrate and benzene metabolites such as catechol and hydroquinone on colony.Circulating CD34+ cells are haemopoietic progenitors that may play a role in tissue repair. No data are available on circulating progenitors in chronic obstructive pulmonary disease (COPD).

Circulating CD34+ cells were studied in 18 patients with moderate-to-severe COPD (age: mean±sd 68±8 yrs; forced expiratory volume in one second: 48±12% predicted) and 12 controls, at rest and after. (A) Ionizing radiation dose effects on cell cycle progression after 24 h (doses: 0, 1, 2, or 3 Gy).

(B) Time course cell cycle analyses following 0 and 3 Gy irradiation (time points:24, or 48 h). Ionizing radiation effects on the KG Ia cell line 0 E. CLAVE et al. Table 1.